References

Czech and Slovak Ophthalmology

123

10.31348/2019/4/1

Original article

Late Postoperative Opacification of a Hydrophobic Acrylic Intraocular Lens AcryNovaTM PC 610Y

Otrošinová

Marianna

https://orcid.org/0000-0002-4279-8976

Novák

Jan

Kvasnička

Jan

Žídek

Ondřej

6 1 2020

Purpose: To report late postoperative opacification of a hydrophobic acrylic intraocular lens (IOL) AcryNovaTMPC 610Y as well as the clinical consequences in patients 10 years after uncomplicated cataract surgery. Materials and Methods: Medical records were reviewed of 23 patients (26 eyes) with AcryNovaTMPC 610Y implantated between years 2005 and 2007. Next clinical examination was performed 10 years after surgery. We assessed best corrected distance visual acuity (BCDVA), contrast sensitivity (CSV-1000E) and relative opacity of IOL material, (OCULUS Pentacam HR). Results of BCDVA and Pentacam were analysed statistically. One explanted IOL was analysed using anterior segment OCT in vitro and spectroscopic method EDX (Energydispersive X-ray spectroscopy). Results: Opacification led to a statistically significant reduction in the best corrected distance visual acuity (BCDVA) = (0,95 ± 0,10) versus (0,87 ± 0,20) and to increase of IOL opacity only in some lenses but statistically significant in the average (6,37 ± 2,16)% versus value of (14,22 ± 5,87)%. In the explanted IOL we have documented structural changes of primarily hydrophobic raw material leading to property of hydrophilic one. Conclusion: Some batches of AcryNovaTMPC 610Y were produced from raw material of poor quality which is the cause of its structural changes and its progressive opacification.

intraocular lens AcryNovaTMPC 610Y material opacification hydrophobic intraocular lens posterior capsule opacification Pentacam

References

Apple, DJ., Peng, Q., Arthur, SN. et al.: Snowflake degeneration of polymethyl methacrylate posterior chamber intraocular lens optic material: A newly described clinical condition caused by unexpected late opacification of polymethyl methacrylate. Ophthalmology, 109; 2002: 1666–1675.

Bompastor-Ramos, P., Povoa, J., Lobo, C. et al.: Late postoperative opacification of a hydrophilic-hydrophobic acrylic intraocular lens. J Cataract Refract Surg, 42; 2016: 1324– 1331.

Buchen, SY., Cunanan, CM., Gwon, A. et al.: Assessing intraocular lens calcification in an animal model. J Cataract Refract Surg, 27; 2001: 1473-1484. ČESKÁ A SLOVENSKÁ OFTALMOLOGIE 4/2019 178

Dagres, E., Khan, MA., Kyle, GM. et al.: Perioperative complications of intraocular lens exchange in patients with opacified Aqua-Sense lenses. J Cataract Refract Surg, 30; 2004: 2569–2573.

De Cock, R., Fajgenbaum, MA.: Calcification of Rayner hydrophilic acrylic intra-ocular lenses after Descemet‘s stripping automated endothelial keratoplasty. Eye (Lond), 28; 2014: 1383–1384.

Dhaliwal, DK., Mamalis, N., Olson, RJ. et al.: Visual significance of glistenings seen in the AcrySof intraocular lens. J Cataract Refract Surg, 22; 1996: 452–457.

Dhital, A., Spalton, DJ., Goyal, S. et al.: Calcification in hydrophilic intraocular lenses associated with injection of intraocular gas. Am J Ophthalmol, 153; 2012: 1154–1160.

Fellman, MA., Werner, L., Liu, ET. et al.: Calcification of a hydrophilic acrylic intraocular lens after Descemet-stripping endothelial keratoplasty: Case report and laboratory analyses. J Cataract Refract Surg, 39; 2013: 799–803.

Gartaganis, SP., Kanellopoulou, DG., Mela, EK. et al.: Opacification of hydrophilic acrylic intraocular lens attributable to calcification: Investigation on mechanism. Am J Ophthalmol, 146; 2008: 395-403.

Gayton, JL., Apple, DJ., Peng, Q. et al.: Interlenticular opacification: clinicopathological correlation of a complication of posterior chamber piggyback intraocular lenses. J Cataract Refract Surg, 26;2000: 330–336.

Gunenc, U., Oner, FH., Tongal, S. et al.: Effects on visual function of glistenings and folding marks in AcrySof intraocular lenses. J Cataract Refract Surg, 27; 2001: 1611–1614.

Hayashi, K., Hirata, A., Yoshida, M. et al: Long-term effect of surface light scattering and glistenings of intraocular lenses on visual function. Am J Ophthalmol, 154; 2012: 240–251.

Haymore, J., Zaidman, G., Werner, L. et al.: Misdiagnosis of hydrophilic acrylic intraocular lens optic opacification: Report of 8 cases with the memoryLens. Ophthalmology, 114; 2007: 1689-1695.

Helvacı, S.: Acute opacification of hydrophobic acrylic intraocular lens during implantation:result of temperature variation. Arq Bras Oftalmol, 78; 2015: 267.

Hollick, EJ., Spalton, DJ., Ursell, PG.: Biocompatibility of poly (methyl methacrylate), silicone, and AcrySof intraocular lenses: randomized comparison of the cellular reaction on the anterior lens surface. J Cataract Refract Surg, 24; 1998: 361–366.

Cheng, JW., Wei, RL., Cai, JP. et al.: Efficacy of different intraocular lens materials and optic edge designs in preventing posterior capsular opacification: a meta-analysis. Am J Ophthalmol, 143; 2007: 428–436.

Izak, AM., Werner, L., Pandey, SK. et al.: Calcification of modern foldable hydrogel intraocular lens designs. Eye (Lond), 17; 2003: 393–406.

Jirásková, N., Rozsíval, P.: Metody hodnocení zkalení zadního pouzdra po operaci katarakty, Cesk Slov Oftalmol, 60; 2004: 155–157.

Liutkeviciene, R., Cebatoriene, D., Liutkeviciene, G. et al.: Associations between contrast sensitivity and aging. Medicina (Kaunas), 49; 2013: 273–277.

Matsushima, H., Mukai, K., Nagata, M. et al.: Analysis of surface whitening of extracted hydrophobic acrylic intraocular lenses. J Cataract Refract Surg, 35; 2009: 1927– 1934.

Morgan-Warren, PJ., Andreatta, W., Patel, AK.: Opacification of hydrophilic intraocular lenses after descemet stripping automated endothelial keratoplasty. Clin Ophthalmol, 9; 2015: 277-283.

Neuhann, IM., Neuhann, TF., Rohrbach, JM.: Intraocular lens calcification after keratoplasty. Cornea, 32; 2013: 6–10.

Neuhann, IM., Werner, L., Izak, AM. et al.: Late postoperative opacification of a hydrophilic acrylic (hydrogel) intraocular lens: A clinicopathological analysis of 106 explants. Ophthalmology, 111; 2004: 2094–2101.

Ogura, Y., Ong, MD., Akinay, A. et al.: Optical performance of hydrophobic acrylic intraocular lenses with surface light scattering. J Cataract Refract Surg, 40; 2014: 104–113.

Ong, MD., Callaghan, TA., Pei, R. et al.: Etiology of surface light scattering on hydrophobic acrylic intraocular lenses. J Cataract Refract Surg, 38; 2012: 1833–1844.

Pandey, SK., Werner, L., Apple, DJ. et al.: Hydrophilic acrylic intraocular lens optic and haptics opacification in a diabetic patient: Bilateral case report and clinicopathologic correlation. Ophthalmology, 109; 2002: 2042–2051.

Pozlerová, J., Nekolová, J., Jirásková, N. et al.: Hodnocení opacit zadního pouzdra u různých typů umělých nitroočních čoček. Cesk Slov Oftalmol, 65; 2009: 12-15.

Prasad, PS., Oliver, SC., Gonzales, CR.: Midlenticular optic opacification of a hydrophobic acrylic intraocular lens in association with retained perfluorocarbon liquid following vitreoretinal surgery. Ophthalmic Surg Lasers Imaging, 9; 2010: 1–2.

Schauersberger, J., Amon, M., Kruger, A. et al: Lens epithelial cell outgrowth on 3 types of intraocular lenses. J Cataract Refract Surg, 27; 2001: 850–854.

Sundelin, K., Friberg-Riad, Y., Ostberg, A. et al.: Posterior capsule opacification with AcrySof and poly (methyl methacrylate) intraocular lenses. Comparative study with a 3-year follow-up. J Cataract Refract Surg, 27; 2001: 1586–1590.

Tandogan, T., Khoramnia, R., Choi, CY. et al.: Optical and material analysis of opacified hydrophilic intraocular lenses after explantation: a laboratory study. BMC Ophthalmology, 15; 2015: 170.

Tetz, M., Jorgensen, MR.: New hydrophobic IOL materials and understanding the science of Glistenings. Curr Eye Res, 40; 2015: 969–981.

Walker, NJ., Saldanha, MJ., Sharp, JA. et al.: Calcification of hydrophilic acrylic intraocular lenses in combined phacovitrectomy surgery. J Cataract Refract Surg, 36; 2010: 1427– 1431.

Weinberg, T., Klein, I., Zadok, D. et al.: Lens epithelial cell growth on the anterior optic of 2 hydrophobic intraocular lens models. J Cataract Refract Surg, 42; 2016: 296–301.

Werner, L.: Causes of intraocular lens opacification or discoloration. J Cataract Refract Surg, 33; 2007: 713–726.

Werner, L.: Glistenings and surface light scattering in intraocular lenses. J Cataract Refract Surg, 36; 2010: 1398–1420.

Werner, L., Michelson, J., Ollerton, A. et al.: Anterior segment optical coherence tomography in the assessment of posoperative intraocular lens optic changes J Cataract Refract Surg, 36; 2012: 1077-1085.

Xi, L., Liu, Y., Zhao, F. et al.: Analysis of glistenings in hydrophobic acrylic intraocular lenses on visual performance. Int J Ophthalmol, 7; 2014: 446–451.