2018 - 1 Issue

Original article

Pachychoroid disease of the macula

Alexandr Stěpanov ORCID
Jan Studnička ORCID – Miroslava Středová – Veronika Fialová ORCID

Full Text links

DOI: 10.31348/2018/1/1-1-2018

Published in Czech and Slovak Ophtalmology: 2018 - 1

Published on website: 03.07.2018

Keywords: optical koherence tomography, OCT, pachychoroid, EDI scan

Summary

Progress in optical coherent tomography (OCT) has recently provided new insights into variety of chorioretinal disorders. The use of EDI (Enhanced Depth Imaging) during OCT examinations and as well as OCT angiography provides a more accurate analysis of the choroid both quantitatively and qualitatively. „Pachychoroid“ (greek pachy- [παχύ]: thick) is defined as an abnormal and sustained increase in choroidal thickness ≥ 300 μm, which is mainly due to dilated choroidal vessels in the Haller’s layer and other structural changes in physiological choroidal architecture. Central serous chorioretinopathy is one of many macular diseases associated with „pachychoroid“. Another diseases that belong to the group of macular pachychoroid disorders are: pachychoroid pigment epitelopathy, pachychoroid neovasculopathy, polypoid choroidal vasculopathy. In this paper we summarize the current view on pachychoroid macular diseases and describe characteristics that are observed in multimodal imaging analysis of choroidal changes.

References

  1. Alam, S., Zawadzki, RJ., Choi, S. et al.: Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging. Ophthalmology, 113(8); 2006: 1425–31.
  2. Aoyagi, R., Hayashi, T., Masai, A. et al.: Subfoveal choroidal thickness in multiple evanescent white dot syndrome. Clin Exp Optom, 95(2); 2012: 212–7.
  3. Arora, S., Pyare, R., Sridharan, P. et al.: Choroidal thickness evaluation of healthy eyes, central serous chorioretinopathy, and fellow eyes using spectral domain optical coherence tomography in Indian population. Indian J Ophthalmol, 64(10); 2016: 747–751.
  4. Azar, G., Wolff, B., Mauget-Faÿsse, M. et al.: Pachychoroid neovasculopathy: aspect on optical coherence tomography angiography. Acta Ophthalmol, 95(4); 2017: 421-427.
  5. Bonini Filho, MA., de Carlo, TE., Ferrara, D. et al.: Association of Choroidal Neovascularization and Central Serous Chorioretinopathy with Optical Coherence Tomography Angiography. JAMA Ophthalmol, 133; 2015: 899–906.
  6. Dansingani, KK., Balaratnasingam, C., Naysan, J. et al.: En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina, 36(3); 2016: 499–516.
  7. de Jong, EK., Breukink, MB., Schellevis, RL. et al.: Chronic central serous chorioretinopathy is associated with genetic variants implicated in age-related macular degeneration. Ophthalmology, 44(4); 2003: 1696–703.
  8. Drexler, W., Morgner, U., Ghanta, RK. et al.: Ultrahigh-resolution ophthalmic optical coherence tomography. Nat Med, 7(5); 2001: 636.
  9. Ersoz, MG., Karacorlu, M., Arf, S. et al.: Outer nuclear layer in pachychoroid pigment epitheliopathy. Retina, 2017: [Epub ahead of print]
  10. Ersoz, MG., Karacorlu, M., Arf, S. et al.: Pachychoroid pigment epitheliopathy in fellow eyes of patients with unilateral central serous chorioretinopathy. Br J Ophthalmol, 2017: [Epub ahead of print]
  11. Freund, KB., Pang, CE.: Pachychoroid Neovasculopathy. Retina, 35; 2015: 1–9.
  12. Fung, AT., Yannuzzi, LA., Freund, KB.: Type 1 (sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration. Retina, 32(9); 2012: 1829–37.
  13. Gass, JDM.: Pathogenesis of disciform detachment of the neuroepithelium. II. Idiopathic central serous choroidopathy. Am J Ophthalmol, 63; 1967: 587– 615.
  14. Gemenetzi, M., De Salvo, G., Lotery, AJ.: Central serous chorioretinopathy: an update on pathogenesis and treatment. Eye, 24; 2010: 1743–1756.
  15. Gloesmann, M., Hermann, B., Schubert, C. et al.: Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci,
  16. Goldenberg, D., Moisseiev, E., Goldstein, M. et al.: Enhanced depth imaging optical coherence tomography: choroidal thickness and correlations with age, refractive error, and axial len- gth. Ophthalmic Surg Lasers Imaging, 43(4); 2012: 296–301.
  17. Huang, D., Swanson, EA., Lin, CP. et al.: Optical coherence tomography. Science, 254(5035); 1991: 1178–81.
  18. Chrapek, O., Řehák, J.: Léčba centrální serózní chorioretinopatie – naše zkušenosti. Čes. a slov. Oftal, 1; 2002: 51-56
  19. Ie, D., Yannuzi, LA., Spaide, RF. et al.: Subretinal exudative deposits in central serous chorioretinopathy. Br J Ophthalmol, 77; 1993: 349–53.
  20. Kawamura, A., Yuzawa, M., Mori, R. et al.: Indocyanine green angiographic and optical coherence tomographic findings support classification of polypoidal choroidal vasculopathy into two types. Acta Ophthalmol, 91(6); 2013: e474–e481.
  21. Lehmann, M., Bousquet, E., Beydoun, T.: Pachychoroid: an inherited condition? Retina, 35(1); 2015: 10-6.
  22. Lin, WY., Yang, SC., Chen, SJ. et al.: Automatic segmentation of polypoidal choroidal vasculopathy from indocyanine green angiography using spatial and temporal patterns. Transl Vis Sci Technol, 4(2); 2015: 7
  23. Margolis, R., Spaide, RF.: A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol, serous chorioretinopathy quantified using swept-source optical coherence tomography. Am J Ophthalmol, 169; 2016: 199–207.
  24. Maruko, I., Iida, T., Sugano, Y. et al.: Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina, 31(3); 2011: 510–7.
  25. Matsumoto, H., Kishi, S., Otani, T. et al.: Elongation of photoreceptor outer segment in central serous chorioretinopathy. Am J Ophthalmol, 145; 2008: 162–8.
  26. Matušková, V.: Centrální serózní cho - rioretinopatie jako maskující syndrom choroidálního hemangiomu. Čes. a slov. Oftal, 72(6); 2016: 209-214
  27. Mrejen, S., Spaide, RF.: Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol, 58(5); 2013: 387–429.
  28. Ojima, A., Iida, T., Sekiryu, T. et al.: Photopigments in central serous chorioretinopathy. Am J Ophthalmol, 151; 2011: 940–52.
  29. Ooto, S., Kuroda, Y., Yoshimura, N.: Increased choroidal vascularity in central panuveitis and punctate inner choroidopathy through multimodal imaging. Retina, 33(7); 2013: 1315–24.
  30. Pang, CE., Freund, KB.: Pachychoroid ne - ovasculopathy. Retina, 35(1); 2015: 1–9.
  31. Pang, CE., Shah, VP., Sarraf, D. et al.: Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serous chorioretinopathy. Am J Ophthalmol, 158(2); 2014: 362– 371.e2.
  32. Rosa, Dolz-Marco., Kunal, K., Dansingani, K.: The pachychoroid clinical spectrum. [online] Retina Today. May/ June 2016. Dostupné na www: .
  33. Spaide, RF., Campeas, L., Haas, A. et al.: Central serous chorioretinopathy in younger and older adults. Ophthalmology, 103; 1996: 2070–9.
  34. Spaide, RF., Goldberg, N., Freund, KB.: Redefining multifocal choroiditis and 147(5); 2009: 811–5.
  35. Spaide, RF., Koizumi, H., Pozzoni, MC.: Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol, 146(4); 2008: 496– 500.
  36. Von Graefe, A.: Uebercentralerecidivi - erende retinitis. Graefes Arch Clin Exp Ophthalmol, 12; 1866: 211–15.
  37. Warrow, DJ., Hoang, QV., Freund, KB.: Pachychoroid pigment epitheliopathy. Retina, 33(8); 2013: 1659–1672.
  38. Yannuzzi, LA., Sorenson, J., Spaide, RF. et al.: Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina, 10(1); 1990: 1-8.
  39. Yoneyama, S., Sakurada, Y., Kikushima, W. et al.: Genetic factors associated with choroidal vascular hyperpermeability and subfoveal choroidal thickness polypoidal choroidal vasculopathy. Retina, 36(8); 2016: 1535-41.