2016 - 2 Issue

Original article

The Effect of Cataract Surgery on the Reproducibility and Outcome of Optical Coherence Tomography Measurements of Macular and Retinal Nerve Fibre Layer Thickness

Petra Pašová
Karolina Skorkovská

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Published in Czech and Slovak Ophtalmology: 2016 - 2

Published on website: 30.04.2016

Keywords: optical coherence tomography, glaucoma, cataract, macular thickness, retinal nerve fibre layer thickness

Summary

Introduction: Optical coherence tomography (OCT) is a non-invasive imaging technique used for the examination of the macula and peripapillary retinal nerve fibre layer (RNFL), the result of which may be affected by the quality of the scanned image. The aim of our study was to assess the influence of uncomplicated cataract extraction on the measurement of macular and RNFL thickness with OCT and to determine the reproducibility of this method before and after cataract surgery in a group of healthy people. We also evaluated the effect of different intraocular lenses (IOL) (with/without yellow filter) on the reproducibility of the OCT examination.

Methods: The study group included 51 eyes of 51 patients who underwent cataract surgery with posterior chamber IOL implantation. Macular and RNFL thickness were measured with spectral domain OCT (Optovue, Model RT 100) one week before surgery, and postoperatively after one and six months. Three OCT scans were performed at each visit to assess the reproducibility of the measurement. Data were statistically processed.

Results: Analysis of the changes in macular and RNFL thickness showed a significant increase in retinal thickness, with the maximum increase one month after surgery, and regression of this thickening six months after surgery. Reproducibility of OCT examination improved significantly after cataract surgery, even though the preoperative values were of low coefficient of variance and therefore of high accuracy. No difference was found in the use of different intraocular lenses on the reproducibility of the OCT examination.

Conclusion: The presence of cataract affects the OCT measurement of macular and RNFL thickness. The reproducibility of the method significantly improves after cataract surgery. It is likely that the increase in macular and RNFL thickness after cataract removal is partly due to improvement in the quality of the scanned image and thus to the greater accuracy of the OCT examination.

References

  1. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science, 1991; 254(5035): 1178–1181.
  2. Schuman JS, Hee MR, Arya AV, et al. Optical coherence tomography: a new tool for glaucoma diagnosis. Curr Opin Ophthalmol, 1995; 6(2): 89–95.
  3. Nassif N, Cense B, Park BH, et al. In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography. Opt Lett, 2004; 29(5): 480–482.
  4. Wojtkowski M, Bajraszewski T, Gorczyńska I, et al. Ophthalmic imaging by spectral optical coherence tomography. Am J Ophthalmol. 2004; 138(3): 412– 419.
  5. van Velthoven ME, Faber DJ, Verbraak FD, van Leeuwen TG, de Smet MD. Re - cent developments in optical coherence tomography for imaging the retina. Prog Retin Eye Res, 2007; 26(1): 57–77.
  6. Uživatelský manuál RTVue-100 v 4.0.
  7. Garcia-Martin E, Pueyo V, Pinilla I, Ara JR, Martin J, Fernandez J. Fourier-domain OCT in multiple sclerosis patients: reproducibility and ability to detect retinal nerve fiber layer atrophy. Invest Ophthalmol Vis Sci, 2011; 52(7): 4124– ní kongres České společnosti refrakční a kataraktové chirurgie, 23.-24.5 2014, Ostrava, ISBN 978-80-87735-12-1.
  8. Bambo MP, Garcia-Martin E, Otin S, et al. Influence of cataract surgery on repeatability and measurements of spectral domain optical coherence tomography. Br J Ophthalmol, 2014; 98(1): 52–58.
  9. Cagini C, Fiore T, Iaccheri B, Piccinelli F, Ricci MA, Fruttini D. Macular thickness measured by optical coherence tomography in a healthy population before and after uncomplicated cataract phacoemulsification surgery. Curr Eye Res, 2009; 34(12): 1036–1041.
  10. Jurečka T, Bátková Z, Ventruba J, Synek S. Makulární edém po operaci katarakty u diabetiků bez diabetické retinopatie. Čes a Slov Oftal, 2007; 63(4): 274–284.
  11. Miyake K, Ibaraki N. Prostaglandins and Cystoid Macular Edema. Survey of Ophthalmology. 2002; 47, Supplement 1(0): S203–S218.
  12. Miyake K, Ibaraki N, Goto Y, et al. ESCRS Binkhorst lecture 2002: Pseudophakic preservative maculopathy. J Cataract Refract Surg, 2003; 29(9): 1800–1810.
  13. Skorkovská Š, Ventruba J. Hodnocení makulárních změn po refrakční výměně čočky. Sborník abstrakt, 12. mezinárod-
  14. El-Ashry M, Appaswamy S, Deokule S, Pagliarini S. The effect of phacoe- mulsification cataract surgery on the measurement of retinal nerve fiber layer thickness using optical coherence tomography. Curr Eye Res, 2006; 31(5): 409–413.
  15. Wu Z, Huang J, Dustin L, Sadda SR. Signal strength is an important determinant of accuracy of nerve fiber layer thickness measurement by optical coherence tomography. J Glaucoma, 2009; 18(3): 213–216.
  16. Kok PH, van den Berg TJ, van Dijk HW, et al. The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography. Acta Ophthalmol, 2013; 91(5): 418–424.
  17. Kim JH, Kim NR, Lee ES, Rho S, Kang SY, Kim CY. Influence of blue light-filtering intraocular lenses on retinal nerve fiber layer measurements by spectraldomain optical coherence tomography. Curr Eye Res, 2011; 36(10): 937–942.